UK-PSC: Primary Sclerosing Cholangitis



What is PSC?
Primary Sclerosing Cholangitis (PSC) is a rare, chronic liver disease which causes, inflammation, fibrosis and obstruction of the bile ducts of the liver. The condition often leads to cirrhosis, end stage liver disease and the need for liver transplantation. There is currently no medical treatment that slows the progression of PSC.

What is the PSC Study?
Set up in 2008, the UK PSC Study aims to identify genetic factors that cause PSC. Over 2000 patients have participated to date.

UK PSC is a Clinical Research Network portfolio study. In 2016 we widened the scope of our research into the causes of PSC, and the study now encompasses:

  • Participation by children in the study
  • Testing for markers in the blood associated with PSC
  • Undertaking deep phenotyping of specific patient groups

This is an exciting time for UK PSC and we are seeking the help of PSC patients of all ages, both new, and already recruited, to the study. This will help us reach our ultimate goal of developing effective treatments.We are also keen to recruit new UK sites and to support existing sites to continue to identify new participants for the study.

Read the Patient Information Sheet




Latest News

COVID-19 Notice

Dear UK-PSC Investigators, Needless to say, the COVID-19 Epidemic is affecting us more ways than one. Our first priority has to be the safety of patients and the wider community. …

New PSC research grant call

PSC Support and UK PSC are inviting applications from UK-based investigators to conduct, ethically approved, biomarker based, research using serum samples collected for the UK-PSC biobank. Two grants of up …

Log in for real time data

Development on the UK PSC database is progressing well and we plan to launch in autumn 2017. The database is an online portal for UK PSC activity at sites and will …

Profiling PSC across all ages

We now have three transplant centres set up as UK PSC paediatric sites: Leeds General Infirmary, Birmingham Children’s Hospital and Kings College Hospital. We recruited our first child to the …